Identification of hypothalamic genes implicated in the. There are two recognised species of psammomys, these being p. The gerbil psammomys obesus is a good model to address questions related to the role of insulin resistance and betacell failure in nutritionally induced diabetes. Rearrange individual pages or entire files in the desired order. The fat sand rat psammomys obesus is the main reservoir host of cutaneous leishmaniasis in north africa and western asia. Energy requirements of fat sand rats psammomys obesus and their.
The fat sand rat psammomys obesus is a terrestrial mammal from the gerbil subfamily that is mostly found in north africa and the middle east, ranging from mauritania to the arabian peninsula. Nutritionally induced diabetes in desert rodents as models of type. Pdf psammomys obesus, a particularly important animal model. Pdf tapeworm identification in the fat sand rat psammomys. This page was last edited on 6 december 2014, at 05. All uploads and downloads are deemed secure and files are permanently deleted from the smallpdf servers within an hour. Reproduction and abundance of the fat sand rat psammomys. Psammomys obesus the israeli sand rat has been well studied as an animal model of type 2 diabetes. The vascular organization of the kidney of psammomys obesus has been studied by injecting silicone rubber into the renal arterial and venous vessels and by standard histological techniques. Mammal species of the world a taxonomic and geographic reference. Psammomys obesus, a particularly important animal model for the study of the human diabetic nephropathy. This species usually lives in sandy deserts, but may also be found in rocky terrain or saline marsh areas. All structured data from the file and property namespaces is available under the creative commons cc0 license. The y chromosome is similar in size to the smallest biarmed autosomes, but.
Whereas the cortical vasculature is not principally different from that of other species, the medullary vessels show some unique features in the psammomys. Reproduction and abundance of the fat sand rat psammomys obesus in relation to weather conditions in tunisia volume 248 issue 1 e. Daytime activities and social interactions in a colony of. Fall 2003 it is our duty as men and women to proceed as though limits to our.
Adolescent changes in the homeostatic and circadian. Psammomys obesus, a particularly important animal model for the study of the human diabetic nephropathy pnina scherzer, 1 shachaf katalan, 1, 2 gay got, 1, 2 galina pizov, 3 irene londono, 4 anca galmoscovici, 1 mordecai m. Characterization of obesity phenotypes in psammomys obesus. Cardiovascular diseases are the most prevalent cause of morbidity and mortality affecting millions of people globally. In order to understand better the transmission of this disease to humans, a longitudinal study of a population of the rodent was carried out in tunisia. Explore factors and population characteristics which contribute to different health outcomes that occur in response to climatic change. Genetic studies in psammomys obesus walder, ken, segal, david, jowett, jeremy, blangero, john, zimmet, paul and collier, greg 2003, genetic studies in psammomys. Myocardial structural and biological anomalies induced by. There are two entries to the drawer under the two caves. The aim of this study was to explore a unique polygenic animal model of metabolic disease as a model of nonalcoholic steatohepatitis by determining the effects of 2% dietary cholesterol supplementation on metabolic and liver endpoints in psammomys obesus israeli sand rat.
Psammomys obesus gerbils are particularly prone to develop diabetes and obesity after brief period of abundant food intake. The psammomys obesus lives in natural desert habitat on low energy le diet, however when maintained in laboratory conditions with high. Wildscreens arkive project was launched in 2003 and grew to become the worlds biggest encyclopaedia of life on earth. Psammomys obesus sand rat, a new animal model of non. Psammomys obesus, a particularly important animal model. Cretzschmar first described psammomys obesus in detail in 1828 from specimens he observed in alexandria, egypt.
With the help of over 7,000 of the worlds best wildlife filmmakers and photographers, conservationists and scientists, featured multimedia fact files for more than 16,000 endangered species. Data analysis methodology for sand rat model syed raza, marc a. Here, we sought to determine whether a short period of. This file is licensed under the creative commons attributionshare alike 4. The fat sand rat psammomys obesus obesus undergoes agere lated sp ontaneous disc degeneration and is an important model for orthopedic stud ies because c hemonucleolysis or surgical in. Role of insulin and the igf system in renal hypertrophy in. The most effective way to counter cardiovascular complications is early diagnosis and the safest noninvasive diagnostic approach is magnetic resonance imaging mri. To change the order of your pdfs, drag and drop the files as you want. Various molecular mechanisms have been proposed to underlie glucoseinduced. Hypoinsulinaemic dm was induced by either administration of streptozotocin or a specially designed diet. Research article electroretinographic evidence suggesting that the type 2 diabetic retinopathy of the sand rat psammomys obesus is comparable to that of humans ahmed dellaa1,2, maha benlarbi1, imane hammoum1, nouha gammoudi3, mohamed dogui3, riadh messaoud4, rached azaiz5, ridha charfeddine5, moncef khairallah4, pierre lachapelle6, rafika ben chaouachachekir1. Pdf psammomys obesus, a particularly important animal.
To induce hyperinsulinaemic dm, psammomys were raised on a high. I system was studied in normal psammomys obesus gerbils and at 5, 15 and 70 days after the induction of either hyper. Leishmania major infection in the fat sand rat psammomys obesus. How can i open multiple pdf files in separate windows. The terrarium has a drawer underneath where they can build a tunnel system. Psammomys is a genus of rodent in the muridae family. Supplementary information appendix materials and methods. Histological sections of liver from animals on both diets were examined for key features of nonalcoholic steatohepatitis. The mean body weight for the colony at 16 weeks of age was 198. The aim of this study was to explore a unique polygenic animal model of metabolic disease as a model of nonalcoholic steatohepatitis by determining the effects of. Daytime activities and social interactions in a colony of the fat sand rats, psammomys obesus, at the negev highlands, israel. Overall, this evidence indicated that the delayed timing of sleep during human adolescence is likely to represent a developmental change common across mammalian species table 1.
Figure 1 shows a frequency histogram for the bodyweightvariable in a total of 633 animals. A hypercaloric high fat diet has been shown to affect cardiac function. Novel genes in the liver of diabetic psammomys obesus. Background and aimsa major impediment to establishing new treatments for nonalcoholic steatohepatitis is the lack of suitable animal models that accurately mimic the biochemical and metabolic characteristics of the disease. Habitat selection by akodon azarae and calomys laucha rodentia, muridae in pampean agroecosystems. The vascular organization of the kidney of psammomys obesus. When they are fed a highenergy he diet, they develop diabetes. Psammomys obesus and determining why this animal model is a major contributor in the research of diabetes. Foraging habits, hunting and breeding success of lanner falcons falco biarmicus in israel reuven yosef 1 mitrani center for desert ecology, blaustein institute for desert research and department of biology, bengurion university, sede boqer campus, 8d993 israel. The sand rat psammomys obesus as an experimental animal in. The sand rat psammomys obesus is a gerbil species native to deserts of north africa and the middle east, and. We analyzed phenotypic data including body weight, percentage body fat, blood glucose and plasma insulin concentration for over 600 animals from the psammomys obesus colony at deakin university to investigate the. The minimal model steady state solution repeating what we did in class.
Psammomys obesus is a unique polygenic animal model of obesity and type 2 diabetes. Behavior of psammomys obesus in the algerian sahara 299 along the saoura, oases occur at intervals of several km, and support tamarix trees, cultivated date palms, and small gardens. In class we studied the minimal model for insulin and glucose. An psammomys obesus in nahilalakip ha genus nga psammomys, ngan familia nga muridae. However, obesity phenotypes in these animals have not been fully characterized. Rapid development of nonalcoholic steatohepatitis in. Seasonal changes in the abundances of parasite and host were monitored in a longitudinal field survey lasting 21 months.
Merge pdf files combine pdfs in the order you want with the easiest pdf merger available. Stages of progression of psammomys obesus to diabetes. Files are available under licenses specified on their description page. Gerbillinae, a diurnal gerbillid rodent, is herbivorous and able to thrive while consuming only the saltbush atriplex. Fat sand rat psammomys obesus longevity, ageing, and.
The expression levels of key genes involved in hepatic lipid metabolism were measured by real. The sand rat has some unique attributes, which make it a valuable experimental animal. The fat sand rat psammomys obesus obesus undergoes agere. An psammomys obesus in uska species han rodentia nga ginhulagway ni philipp jakob cretzschmar hadton 1828. Psammomys continued on page 2 tamara giles, student, howard. The occurrence of increased plasma insulin levels and of hyperglycem. In this study, superparamagnetic ferrite nanoparticles doped with zinc, exhibiting highly enhanced saturation. Identification of hypothalamic genes implicated in the development of obesity in psammomys obesus using differential display pcr. Psammomys obesus were cultured by the explant technique 9. On the feeding ecology of psamommys obesus rodentia, gerbillidae in the wadi saoura, algeria pdf. How can i open pdf files in separate window my pdf. The sand rat, psammomys obesus, develops type 2 diabetic. Islet protection and amelioration of diabetes type 2 in. If the inline pdf is not rendering correctly, you can download the pdf file here.
A major impediment to establishing new treatments for nonalcoholic steatohepatitis is the. Pdf the identification of a tapeworm rodentolepis nana, formerly named hymenolepis. Systems medicine exe 1 weizmann institute of science. Impact of glucotoxicity induced in vivo and in vitro in. What links here related changes upload file special pages permanent link page information wikidata item. Infection prevalence was positively correlated with vector phlebotomus papatasi density but not with host density. Before you combine the files into one pdf file, use merge pdf to draganddrop pages to reorder or to delete them as you like. Imidacloprid as a potential agent for the systemic control. Toumi a, chlif s, bettaieb j, alaya nb, boukthir a, et al. Rowton1 1division of entomology, walter reed army institute of research, 530 robert grant ave. Temporal dynamics and impact of climate factors on the. The control aorta was removed and immediately plunged in a petri dish containing dulbeccos modified eagles medium dmem with 10% fetal calf serum fcs supplemented with 1% antibiotics streptomycin 50mgml, penicillin 50 iuml, sigma, 1. Psammomys obesus sand rat is a wellestablished model of type2 diabetes and obesity, which shares most metabolic parameters of the human metabolic syndrome. Psammomys obesus, a particularly important animal model for the.
1376 56 725 98 591 424 884 635 619 212 418 9 481 1284 1620 1575 75 1284 1660 390 1335 1631 510 143 510 1510 70 364 338 1004 833 1263 1161 1326 478 91 1346 856 567